Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL930093 | 0.86 | ESR1 (0.48) | ALDH1A1HPGDKMT2AMAPTMEN1 | |
| SCHEMBL931338 | 0.79 | GAA (0.43) | ALDH1A1KDM4ESMN1; SMN2KMT2AMAPT | |
| SCHEMBL6408096 | 0.78 | PRKCZ (0.43) | ALDH1A1TP53KMT2AMAPTMEN1 | |
| SCHEMBL931683 | 0.74 | NOTUM (0.39) | KMT2AMEN1NPC1POLBRAB9A | |
| SCHEMBL4933212 | 0.73 | ESR1 (0.50) | ALDH1A1HPGDKMT2AMAPTMEN1 | |
| SCHEMBL930860 | 0.72 | GAA (0.42) | ALDH1A1KDM4ETP53KMT2AMAPT | |
| SCHEMBL931653 | 0.71 | GAA (0.45) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL929867 | 0.71 | PRKCZ (0.43) | KMT2AMAPTMEN1MAPK1NOTUM | |
| SCHEMBL932183 | 0.71 | GAA (0.40) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL932177 | 0.71 | ESR1 (0.48) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021364-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2008-02-21 | — | — | WO | disclosed |