Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812011 | 0.82 | ACHE (0.37) | ACHELDHADAOMAPK8DYRK1A | |
| SCHEMBL14269088 | 0.73 | CDK9 (0.48) | ACHELDHAMAPK8DYRK1ACLK4 | |
| SCHEMBL4032497 | 0.71 | CDK9 (0.46) | ACHEDYRK1AHPGDKDM4ECCNT1 | |
| SCHEMBL4034265 | 0.70 | FEN1 (0.35) | ACHEFEN1CYP1A2CYP2C19MAPT | |
| SCHEMBL4027865 | 0.67 | MAPK8 (0.43) | LDHADAOMAPK8DYRK1ACLK4 | |
| SCHEMBL14269066 | 0.62 | MAPK8 (0.41) | MAPK8DYRK1ACLK4DYRK1B | |
| SCHEMBL8801077 | 0.62 | AHR (0.48) | DAOAXLPIM1 | |
| SCHEMBL12165666 | 0.59 | ACHE (0.47) | ACHELDHAHPGDFEN1CYP2C19 | |
| SCHEMBL25940658 | 0.59 | FEN1 (0.46) | DYRK1AHPGDFEN1CYP1A2CYP2C19 | |
| SCHEMBL30421286 | 0.58 | AXL (0.53) | MAPK8DYRK1ACLK4DYRK1BAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329666-B2 | Derivatives of variolin B | PHARMA MAR, S.A. (ES) | 2008-02-12 | — | — | US | disclosed |