Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | DRD1 | P21728 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | DRD5 | P21918 | 2/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15821433 | 1.00 | DRD2 (0.50) | DRD2DRD1HTR1AADRA2AADRA2B | |
| SCHEMBL14299338 | 1.00 | DRD2 (0.50) | DRD2DRD1HTR1AADRA2AADRA2B | |
| SCHEMBL14299347 | 0.83 | DRD2 (0.51) | DRD2DRD1HTR1AADRA2AADRA2B | |
| SCHEMBL15822843 | 0.83 | DRD2 (0.51) | DRD2DRD1HTR1AADRA2AADRA2B | |
| SCHEMBL15825706 | 0.83 | DRD2 (0.51) | DRD2DRD1HTR1AADRA2AADRA2B | |
| SCHEMBL17272307 | 0.83 | DRD2 (0.51) | DRD2DRD1HTR1AADRA2AADRA2B | |
| SCHEMBL15251760 | 0.80 | DRD2 (0.48) | DRD2DRD1HTR2AHTR2CHTR2B | |
| SCHEMBL3803961 | 0.80 | DRD2 (0.48) | DRD2DRD1HTR2AHTR2CHTR2B | |
| SCHEMBL2069258 | 0.80 | DRD2 (0.48) | DRD2DRD1HTR2AHTR2CHTR2B | |
| SCHEMBL5620402 | 0.80 | DRD2 (0.48) | DRD2DRD1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943460-B1 | 6-CHLORO-3-(PHENYL-D5)-INDEN-1-ONE AND USE THEREOF | H LUNDBECK AS (DK) | 2020-02-12 | — | — | EP | claimed |
| US-9309165-B2 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof | H. LUNDBECK A/S (DK) | 2016-04-12 | — | — | US | claimed |
| US-20150336867-A1 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof | H. LUNDBECK A/S (DK) | 2015-11-26 | — | — | US | claimed |
| EP-2943460-A2 | 6-CHLORO-3-(PHENYL-D5)-INDEN-1-ONE AND USE THEREOF | H. Lundbeck A/S (DK) | 2015-11-18 | — | — | EP | claimed |
| WO-2014096151-A2 | 6-CHLORO-3-(PHENYL-D5)-INDEN-1-ONE AND USE THEREOF | H. LUNDBECK A/S (DK) | 2014-06-26 | — | — | WO | claimed |
| EP-2943460-B1 | 6-CHLORO-3-(PHENYL-D5)-INDEN-1-ONE AND USE THEREOF | H LUNDBECK AS (DK) | 2020-02-12 | — | — | EP | disclosed |
| US-9309165-B2 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof | H. LUNDBECK A/S (DK) | 2016-04-12 | — | — | US | disclosed |
| US-20150336867-A1 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof | H. LUNDBECK A/S (DK) | 2015-11-26 | — | — | US | disclosed |
| US-8575174-B2 | Deuterated 1-piperazino-3-phenyl-indanes for treatment of schizophrenia | H. LUNDBECK A/S (DK) | 2013-11-05 | — | — | US | disclosed |
| US-20130281436-A1 | DEUTERATED 1-PIPERAZINO-3-PHENYL INDANES FOR TREATMENT OF SCHIZOPHRENIA | H. LUNDBECK A/S (DK) | 2013-10-24 | — | — | US | disclosed |
| US-20120322811-A1 | DEUTERATED 1-PIPERAZINO-3-PHENYL-INDANES FOR TREATMENT OF SCHIZOPHRENIA | H. LUNDBECK A/S (DK) | 2012-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322811-A1 | DEUTERATED 1-PIPERAZINO-3-PHENYL-INDANES FOR TREATMENT OF SCHIZOPHRENIA | HTR2C, DRD2, HTR2A | DRD2 2/4885DRD1 9/4885HTR1A 8/4885 |
| US-20130281436-A1 | DEUTERATED 1-PIPERAZINO-3-PHENYL INDANES FOR TREATMENT OF SCHIZOPHRENIA | HTR2C, DRD2, HTR2A | DRD2 2/4885DRD1 8/4885HTR1A 7/4885 |
| US-20150336867-A1 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof | CYP2D6, UGT1A6, IDO1 | DRD2 27/4885DRD1 23/4885HTR1A 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.