Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | DRD1 | P21728 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | DRD5 | P21918 | 2/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15825706 | 1.00 | DRD2 (0.51) | DRD2DRD1HTR1AADRA2AADRA2B | |
| SCHEMBL17272307 | 1.00 | DRD2 (0.51) | DRD2DRD1HTR1AADRA2AADRA2B | |
| SCHEMBL15822843 | 1.00 | DRD2 (0.51) | DRD2DRD1HTR1AADRA2AADRA2B | |
| SCHEMBL14299338 | 0.83 | DRD2 (0.50) | DRD2DRD1HTR1AADRA2AADRA2B | |
| SCHEMBL14299346 | 0.83 | DRD2 (0.50) | DRD2DRD1HTR1AADRA2AADRA2B | |
| SCHEMBL15821433 | 0.83 | DRD2 (0.50) | DRD2DRD1HTR1AADRA2AADRA2B | |
| SCHEMBL2152822 | 0.79 | DRD2 (0.49) | DRD2DRD1HTR2AHTR2CHTR2B | |
| SCHEMBL6055982 | 0.79 | DRD2 (0.49) | DRD2DRD1HTR2AHTR2CHTR2B | |
| SCHEMBL2070013 | 0.79 | DRD2 (0.49) | DRD2DRD1HTR2AHTR2CHTR2B | |
| SCHEMBL7320995 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943460-B1 | 6-CHLORO-3-(PHENYL-D5)-INDEN-1-ONE AND USE THEREOF | H LUNDBECK AS (DK) | 2020-02-12 | — | — | EP | claimed |
| US-9309165-B2 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof | H. LUNDBECK A/S (DK) | 2016-04-12 | — | — | US | claimed |
| US-20150336867-A1 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof | H. LUNDBECK A/S (DK) | 2015-11-26 | — | — | US | claimed |
| EP-2943460-A2 | 6-CHLORO-3-(PHENYL-D5)-INDEN-1-ONE AND USE THEREOF | H. Lundbeck A/S (DK) | 2015-11-18 | — | — | EP | claimed |
| WO-2014096151-A2 | 6-CHLORO-3-(PHENYL-D5)-INDEN-1-ONE AND USE THEREOF | H. LUNDBECK A/S (DK) | 2014-06-26 | — | — | WO | claimed |
| US-12071416-B2 | Prodrugs of 4-( (1R, 3S)-6-chloro-3-phenyl-2, 3-dihydro-1H-inden-1-yl)-1,2, 2-trimethylpiperazine and 4-( (1R, 3S)-6-chloro-3-(phenyl-D5)-2, 3-dihydro-1H-inden-1-yl)-2, 2-dimethyl-1 (methyl-D3) piperazine | H. LUNDBECK A/S (DK) | 2024-08-27 | — | — | US | disclosed |
| US-20230159478-A1 | PRODRUGS OF 4- ( (1R, 3S) -6-CHLORO-3-PHENYL-2, 3-DIHYDRO-1H-INDEN-1-YL) -1,2, 2-TRIMETHYLPIPERAZINE AND 4- ( (1R, 3S)-6-CHLORO-3- (PHENYL-D5) -2, 3-DIHYDRO-1H-INDEN-1-YL) -2, 2-DIMETHYL-1 (METHYL-D3) PIPERAZINE | H. LUNDBECK A/S (DK) | 2023-05-25 | — | — | US | disclosed |
| US-11535600-B2 | Prodrugs of 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl-1-(methyl-d3)piperazine | H. LUNDBECK A/S (DK) | 2022-12-27 | — | — | US | disclosed |
| US-20220033367-A1 | PRODRUGS OF 4-((1R, 3S)-6-CHLORO-3-PHENYL-2,3-DIHYDRO-1H-INDEN-1-Y)-1-,2,2-TRIMETHYLPIPERAZINE AND 4-((1R,3S)-6-CHLORO-3-(PHENYL-D5)-2,3-DIHYDRO-1H-INDEN-1YL)-2,2-DIMETHYL-1 (METHYL-D3)PIPERAZINE | H. LUNDBECK A/S (DK) | 2022-02-03 | — | — | US | disclosed |
| EP-3891134-A1 | PRODRUGS OF 4-((1R,3S)-6-CHLORO-3-PHENYL-2,3-DIHYDRO-1H-INDEN-1-YL)-1,2,2-TRIMETHYLPIPERAZINE AND 4-((1/R,3S)-6-CHLORO-3-(PHENYL-D5)-2,3-DIHYDRO-1H-INDEN-1-YL)-2,2-DIMETHY-1-(METHYL-D3)PIPERAZINE | H. Lundbeck A/S (DK) | 2021-10-13 | — | — | EP | disclosed |
| WO-2020114853-A1 | PRODRUGS OF 4-((1R,3S)-6-CHLORO-3-PHENYL-2,3-DIHYDRO-1H-INDEN-1-YL)-1,2,2-TRIMETHYLPIPERAZINE AND 4-((1/R,3S)-6-CHLORO-3-(PHENYL-D5)-2,3-DIHYDRO-1H-INDEN-1-YL)-2,2-DIMETHY-1-(METHYL-D3)PIPERAZINE | H. LUNDBECK A/S (DK) | 2020-06-11 | — | — | WO | disclosed |
| EP-2943460-B1 | 6-CHLORO-3-(PHENYL-D5)-INDEN-1-ONE AND USE THEREOF | H LUNDBECK AS (DK) | 2020-02-12 | — | — | EP | disclosed |
| US-9309165-B2 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof | H. LUNDBECK A/S (DK) | 2016-04-12 | — | — | US | disclosed |
| US-20150336867-A1 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof | H. LUNDBECK A/S (DK) | 2015-11-26 | — | — | US | disclosed |
| EP-2943460-A2 | 6-CHLORO-3-(PHENYL-D5)-INDEN-1-ONE AND USE THEREOF | H. Lundbeck A/S (DK) | 2015-11-18 | — | — | EP | disclosed |
| WO-2014096151-A2 | 6-CHLORO-3-(PHENYL-D5)-INDEN-1-ONE AND USE THEREOF | H. LUNDBECK A/S (DK) | 2014-06-26 | — | — | WO | disclosed |
| US-8575174-B2 | Deuterated 1-piperazino-3-phenyl-indanes for treatment of schizophrenia | H. LUNDBECK A/S (DK) | 2013-11-05 | — | — | US | disclosed |
| US-20130281436-A1 | DEUTERATED 1-PIPERAZINO-3-PHENYL INDANES FOR TREATMENT OF SCHIZOPHRENIA | H. LUNDBECK A/S (DK) | 2013-10-24 | — | — | US | disclosed |
| US-20120322811-A1 | DEUTERATED 1-PIPERAZINO-3-PHENYL-INDANES FOR TREATMENT OF SCHIZOPHRENIA | H. LUNDBECK A/S (DK) | 2012-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322811-A1 | DEUTERATED 1-PIPERAZINO-3-PHENYL-INDANES FOR TREATMENT OF SCHIZOPHRENIA | HTR2C, DRD2, HTR2A | DRD2 2/4885DRD1 9/4885HTR1A 8/4885 |
| US-20130281436-A1 | DEUTERATED 1-PIPERAZINO-3-PHENYL INDANES FOR TREATMENT OF SCHIZOPHRENIA | HTR2C, DRD2, HTR2A | DRD2 2/4885DRD1 8/4885HTR1A 7/4885 |
| US-12071416-B2 | Prodrugs of 4-( (1R, 3S)-6-chloro-3-phenyl-2, 3-dihydro-1H-inden-1-yl)-1,2, 2-trimethylpiperazine and 4-( (1R, 3S)-6-chloro-3-(phenyl-D5)-2, 3-dihydro-1H-inden-1-yl)-2, 2-dimethyl-1 (methyl-D3) piperazine | SIGMAR1, HTR3C, DRD3 | DRD2 17/4885DRD1 58/4885HTR1A 102/4885 |
| US-20150336867-A1 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof | CYP2D6, UGT1A6, IDO1 | DRD2 27/4885DRD1 23/4885HTR1A 67/4885 |
| US-20220033367-A1 | PRODRUGS OF 4-((1R, 3S)-6-CHLORO-3-PHENYL-2,3-DIHYDRO-1H-INDEN-1-Y)-1-,2,2-TRIMETHYLPIPERAZINE AND 4-((1R,3S)-6-CHLORO-3-(PHENYL-D5)-2,3-DIHYDRO-1H-INDEN-1YL)-2,2-DIMETHYL-1 (METHYL-D3)PIPERAZINE | HTR1D, HTR3C, ITPR3 | DRD2 21/4885DRD1 61/4885HTR1A 32/4885 |
| US-11535600-B2 | Prodrugs of 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl-1-(methyl-d3)piperazine | HTR3C, ITPR3, HTR1D | DRD2 17/4885DRD1 78/4885HTR1A 65/4885 |
| US-20230159478-A1 | PRODRUGS OF 4- ( (1R, 3S) -6-CHLORO-3-PHENYL-2, 3-DIHYDRO-1H-INDEN-1-YL) -1,2, 2-TRIMETHYLPIPERAZINE AND 4- ( (1R, 3S)-6-CHLORO-3- (PHENYL-D5) -2, 3-DIHYDRO-1H-INDEN-1-YL) -2, 2-DIMETHYL-1 (METHYL-D3) PIPERAZINE | SIGMAR1, HTR3C, DRD3 | DRD2 17/4885DRD1 58/4885HTR1A 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.