Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1904633 | 0.84 | POLQ (0.50) | ALDH1A1TSHRGLAKMT2AMEN1 | |
| SCHEMBL3452581 | 0.83 | ALDH1A1 (0.47) | ALDH1A1TSHRGLAMTNR1AMTNR1B | |
| SCHEMBL15320269 | 0.83 | TSHR (0.50) | ALDH1A1TSHRGLAMTNR1AMTNR1B | |
| SCHEMBL2083223 | 0.80 | MTNR1A (0.48) | ALDH1A1TSHRGLAMTNR1AMTNR1B | |
| SCHEMBL27820732 | 0.78 | PARP1 (0.49) | ALDH1A1TSHRGLAMTNR1AMTNR1B | |
| SCHEMBL2277577 | 0.75 | ALDH1A1 (0.37) | ALDH1A1TSHRGLAKMT2AMEN1 | |
| SCHEMBL28408743 | 0.73 | PARP1 (0.44) | ALDH1A1TSHRGLAMTNR1AMTNR1B | |
| SCHEMBL1600710 | 0.72 | HDAC8 (0.41) | ALDH1A1TSHRGLAMTNR1AMTNR1B | |
| SCHEMBL10577047 | 0.72 | ALDH1A1 (0.40) | ALDH1A1TSHRGLAGAAKMT2A | |
| SCHEMBL2475462 | 0.72 | ALDH1A1 (0.44) | ALDH1A1TSHRGLAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300463-A1 | HETEROCYCLIC UREA DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |
| US-7897607-B2 | Cyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-01 | — | — | US | disclosed |