Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 7/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14300690 | 1.00 | FFAR4 (0.38) | FFAR4NOTUMCYP3A4USP2HSD17B10 | |
| SCHEMBL14300689 | 0.88 | FFAR4 (0.38) | FFAR4NOTUMCYP3A4USP2HSD17B10 | |
| SCHEMBL14300691 | 0.88 | FFAR4 (0.38) | FFAR4NOTUMCYP3A4USP2HSD17B10 | |
| SCHEMBL1410213 | 0.83 | ALDH1A1 (0.36) | FFAR4USP2HSD17B10CYP2C9LMNA | |
| SCHEMBL1410097 | 0.81 | ADRB1 (0.37) | FFAR4NOTUMADRB1POLBHIF1A | |
| SCHEMBL1410217 | 0.78 | FFAR4 (0.37) | FFAR4NOTUMUSP2HIF1A | |
| SCHEMBL1410260 | 0.73 | FFAR4 (0.44) | FFAR4NOTUMADRB1LMNA | |
| SCHEMBL1410216 | 0.68 | FFAR4 (0.37) | FFAR4NOTUMUSP2HSD17B10HIF1A | |
| SCHEMBL1410214 | 0.66 | FFAR4 (0.37) | FFAR4NOTUMHSD17B10POLBHIF1A | |
| SCHEMBL1410258 | 0.66 | FFAR4 (0.44) | FFAR4NOTUMADRB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295406-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL (JP) | 2014-04-23 | — | — | EP | disclosed |
| US-8338622-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-12-25 | — | — | US | disclosed |
| EP-2295406-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-03-16 | — | — | EP | disclosed |