Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SCN4A | P35499 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL767862 | 0.86 | TSHR (0.65) | TSHRKMT2ASMN1; SMN2ALOX15SCN4A | |
| SCHEMBL767863 | 0.86 | TSHR (0.65) | TSHRKMT2ASMN1; SMN2ALOX15SCN4A | |
| SCHEMBL14306154 | 0.84 | TSHR (0.63) | TSHRKMT2ASMN1; SMN2ALOX15SCN4A | |
| SCHEMBL14301111 | 0.84 | TSHR (0.63) | TSHRKMT2ASMN1; SMN2ALOX15SCN4A | |
| SCHEMBL772928 | 0.83 | TSHR (0.61) | TSHRKMT2ASMN1; SMN2ALOX15SCN4A | |
| SCHEMBL772838 | 0.83 | SCN4A (0.68) | TSHRKMT2ASMN1; SMN2ALOX15SCN4A | |
| SCHEMBL773113 | 0.79 | TSHR (0.60) | TSHRKMT2ASMN1; SMN2ALOX15SCN4A | |
| SCHEMBL773062 | 0.79 | TSHR (0.93) | TSHRKMT2ASMN1; SMN2ALOX15SCN4A | |
| SCHEMBL23837136 | 0.74 | LMNA (0.39) | TSHRKMT2ASMN1; SMN2SCN4AMAPT | |
| SCHEMBL772851 | 0.74 | TSHR (0.68) | TSHRKMT2ASMN1; SMN2ALOX15SCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |