Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1179394 | 0.84 | TRPA1 (0.54) | TRPA1MAPK1NPC1HPGDHTT | |
| SCHEMBL9745054 | 0.78 | NPC1 (0.59) | TRPA1MAPK1NPC1HPGDHTT | |
| SCHEMBL16528474 | 0.78 | TRPA1 (0.48) | TRPA1MAPK1NPC1HPGDHTT | |
| SCHEMBL992788 | 0.76 | TRPA1 (0.46) | TRPA1MAPK1NPC1HPGDHTT | |
| SCHEMBL1173818 | 0.76 | TRPA1 (0.56) | TRPA1MAPK1NPC1HPGDHTT | |
| SCHEMBL508967 | 0.75 | HSPA5 (0.39) | TRPA1HPGDBACE1MAPTKDM4E | |
| SCHEMBL14304473 | 0.75 | HSPA5 (0.39) | TRPA1HPGDBACE1MAPTKDM4E | |
| SCHEMBL9744115 | 0.75 | NPC1 (0.80) | TRPA1MAPK1NPC1HPGDHTT | |
| SCHEMBL3182711 | 0.74 | SELL (0.52) | TRPA1MAPK1NPC1HPGDHTT | |
| SCHEMBL67845 | 0.74 | TRPA1 (0.54) | TRPA1MAPK1NPC1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051326-A1 | Antiinfective Lipopeptides | CUBIST PHARMACEUTICALS, INC. | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051326-A1 | Antiinfective Lipopeptides | VIP, NGLY1, PREP | TRPA1 3083/4885MAPK1 3260/4885NPC1 956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.