Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.54 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 4/20 | 0.43 |
| ▸ | HTR1B | P28222 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3652845 | 0.87 | GABRA1 (0.65) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL1430339 | 0.86 | GABRA1 (0.55) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL3719277 | 0.85 | HTR2A (0.46) | MEN1KMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL3725502 | 0.84 | HTR2A (0.45) | KMT2AHTR1DHTR1BHTR1A | |
| SCHEMBL1430455 | 0.83 | GABRA1 (0.65) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL1430085 | 0.79 | GABRA1 (0.47) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL5514815 | 0.79 | GABRA1 (0.63) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL1430314 | 0.78 | GABRA1 (0.47) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL7845688 | 0.77 | GABRA1 (0.58) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL1242568 | 0.76 | GABRA1 (0.70) | GABRA1GABRB2GABRB1GABRA3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300463-A1 | HETEROCYCLIC UREA DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |
| WO-2010142978-A1 | HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-12-16 | — | — | WO | disclosed |
| WO-2009147433-A1 | HETEROCYCLIC UREA DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2009-12-10 | — | — | WO | disclosed |