Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 4/20 | 0.44 |
| ▸ | HTR1B | P28222 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725502 | 0.89 | HTR2A (0.45) | HTR2AHTR2CHTR2BKMT2AHTR1D | |
| SCHEMBL1430296 | 0.85 | GABRA1 (0.54) | KMT2AMEN1HTR1DHTR1BHTR1A | |
| SCHEMBL3646574 | 0.84 | HTT (0.51) | KDM4EKMT2AMEN1ADRB2RECQL | |
| SCHEMBL4961480 | 0.83 | HTT (0.48) | KDM4EKMT2AMEN1HTTHPGD | |
| SCHEMBL8913208 | 0.79 | HTT (0.51) | KDM4EKMT2AMEN1ADRB2RECQL | |
| SCHEMBL4960045 | 0.78 | KDM4E (0.49) | KDM4EKMT2AMEN1ADRB2RECQL | |
| SCHEMBL5238370 | 0.78 | KDM4E (0.46) | KDM4EKMT2AMEN1HTTHPGD | |
| SCHEMBL5515830 | 0.73 | KDM4E (0.52) | KDM4EKMT2AMEN1HTTHPGD | |
| SCHEMBL11022445 | 0.72 | KDM4E (0.55) | KDM4EKMT2AMEN1HTTHPGD | |
| SCHEMBL1429717 | 0.72 | KDM4E (0.45) | KDM4EKMT2AMEN1HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010142978-A1 | HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-12-16 | — | — | WO | disclosed |