Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.46 |
| ▸ | HTR1D | P28221 | 8/20 | 0.46 |
| ▸ | HTR1A | P08908 | 5/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 4/20 | 0.41 |
| ▸ | SLC18A2 | Q05940 | 2/20 | 0.40 |
| ▸ | SLC18A1 | P54219 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11493969 | 0.72 | HTR2A (0.54) | HTR2AHTR1DHTR1AHTR2CHTR2B | |
| SCHEMBL25423069 | 0.72 | HTR2A (0.44) | HTR2AHTR1DHTR1AHTR2CHTR2B | |
| SCHEMBL31077765 | 0.72 | HTR2A (0.44) | HTR2AHTR1DHTR1AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL25424469 | 0.71 | HTR2A (0.43) | HTR2AHTR1DHTR1AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL31440930 | 0.71 | HTR2A (0.43) | HTR2AHTR1DHTR1AHTR2CHTR2B | |
| SCHEMBL4922401 | 0.71 | ALDH1A1 (0.46) | SLC18A2SLC18A1CYP1A2TSHRMAPT | |
| SCHEMBL1587240 | 0.69 | HTR2A (0.57) | HTR2AHTR1DHTR1AHTR2CHTR1B | |
| SCHEMBL4838821 | 0.69 | GPR84 (0.69) | HTR2AHTR1DHTR1AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7816598 | 0.69 | HTR2A (0.58) | HTR2AHTR1DHTR1AHTR2CHTR2B | |
| SCHEMBL26965701 | 0.69 | HTR2C (0.56) | HTR2AHTR1DHTR1AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130190497-A1 | FLUORESCENT SUBSTRATES FOR MONOAMINE TRANSPORTERS AS OPTICAL FALSE NEUROTRANSMITTERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2013-07-25 | — | — | US | disclosed |
| US-8337941-B2 | Fluorescent substrates for monoamine transporters as optical false neurotransmitters | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-12-25 | — | — | US | disclosed |
| WO-2008013997-A2 | FLUORESCENT SUBSTRATES FOR MONOAMINE TRANSPORTERS AS OPTICAL FALSE NEUROTRANSMITTERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190497-A1 | FLUORESCENT SUBSTRATES FOR MONOAMINE TRANSPORTERS AS OPTICAL FALSE NEUROTRANSMITTERS | SLC18A2, SLC6A2, SLC18A3 | HTR2A 110/4885HTR1D 220/4885HTR1A 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.