Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL456312 | 0.84 | APP (0.50) | SMN1; SMN2KMT2AKDM4EAPPTSHR | |
| SCHEMBL6256165 | 0.80 | MAPK1 (0.73) | SMN1; SMN2KMT2AKDM4ETSHRMAPK1 | |
| SCHEMBL773103 | 0.80 | ADRB2 (0.64) | SMN1; SMN2KMT2ATSHRMAPK1HIF1A | |
| SCHEMBL17277327 | 0.80 | ADRB2 (0.64) | SMN1; SMN2KMT2ATSHRMAPK1HIF1A | |
| SCHEMBL17277360 | 0.80 | ADRB2 (0.64) | SMN1; SMN2KMT2ATSHRMAPK1HIF1A | |
| SCHEMBL7396426 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2AKDM4EAPPTSHR | |
| SCHEMBL12075476 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2KMT2AKDM4ETSHRMAPK1 | |
| SCHEMBL12075867 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2KMT2AKDM4ETSHRMAPK1 | |
| SCHEMBL29686538 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2KMT2AKDM4ETSHRMAPK1 | |
| SCHEMBL20082427 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2KMT2AKDM4ETSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |