SCHEMBL456312

SCHEMBL456312

CNc1cccc(OCC(N)O)c1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
APP P05067 1/20 0.50
KDM4E B2RXH2 1/20 0.47
SIRT2 Q8IXJ6 1/20 0.44
TSHR P16473 1/20 0.43
MAPK1 P28482 1/20 0.43
HIF1A Q16665 1/20 0.43
ADRB2 P07550 1/20 0.41
ADRB1 P08588 1/20 0.41
HTR1D P28221 1/20 0.40
HTR1B P28222 1/20 0.40
LMNA P02545 1/20 0.40
NR1H4 Q96RI1 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
MTNR1A P48039 3/20 0.38
MTNR1B P49286 3/20 0.38
MAPT P10636 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14306155 0.84 SMN1; SMN2 (0.51) APPKDM4ESIRT2TSHRMAPK1
SCHEMBL7785622 0.76 APP (0.49) APPTSHRMAPK1HIF1ASMN1; SMN2
SCHEMBL8306841 0.75 APP (0.58) APPMAPK1LMNANR1H4MEN1
SCHEMBL8310702 0.75 APP (0.54) APPKDM4ETSHRMAPK1LMNA
SCHEMBL19743630 0.75 APP (0.54) APPKDM4ETSHRMAPK1
SCHEMBL479065 0.74 NPC1 (0.50) APPMAPK1LMNAMEN1KMT2A
SCHEMBL1369854 0.73 LMNA (0.63) KDM4ETSHRHIF1AADRB2ADRB1
SCHEMBL18088138 0.73 APP (0.55) APPKDM4EMAPK1MEN1KMT2A
SCHEMBL5609143 0.73 APP (0.55) APPKDM4ETSHRMAPK1LMNA
SCHEMBL12017469 0.72 MAPK1 (0.64) APPMAPK1LMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2709585-A2 AMMONIUM HYDROXYDE-FREE HAIR DYE COMPOSITIONS CONTAINING A BUFFER SYSTEM Alfa Parf Group S.p.a. (IT) 2014-03-26 EP disclosed
WO-2013131575-A1 FOAMABLE COLORING COMPOSITIONS COMPRISING A THERMO-SENSITIVE POLYMER ALFAPARF GROUP S.P.A. (IT) 2013-09-12 WO disclosed
EP-2613760-A2 COMPOSITIONS FOR DYEING KERATIN FIBERS Segetis, Inc. (US) 2013-07-17 EP disclosed
WO-2012156953-A2 AMMONIUM HYDROXYDE-FREE HAIR DYE COMPOSITIONS CONTAINING A BUFFER SYSTEM ALFA PARF GROUP S.P.A. (IT) 2012-11-22 WO disclosed
WO-2012033813-A2 COMPOSITIONS FOR DYEING KERATIN FIBERS SEGETIS, INC. (US) 2012-03-15 WO disclosed
EP-2211657-A2 AIR OXIDATION HAIR DYE APPLICATION SYSTEM AND METHOD FOR COLORING HAIR USING THE SAME Combe International Ltd. (US) 2010-08-04 EP disclosed
WO-2009058700-A2 AIR OXIDATION HAIR DYE APPLICATION SYSTEM AND METHOD FOR COLORING HAIR USING THE SAME COMBE INTERNATIONAL LTD. (US) 2009-05-07 WO disclosed
WO-2008102310-A1 DYES FOR KERATINIC FIBERS COMPRISING A SPECIAL ANIONIC THICKENER THE PROCTER & GAMBLE COMPANY (US) 2008-08-28 WO disclosed
EP-1919440-A2 AGENT FOR SIMULTANEOUS LIGHTENING AND COLORING OF KERATIN FIBRES CONTAINING A SULFAMATE BLEACH BOOSTER The Procter and Gamble Company (US) 2008-05-14 EP disclosed
EP-1855641-A1 DYE CARRIER MASS Wella Aktiengesellschaft (DE) 2007-11-21 EP disclosed
WO-2007026328-A2 AGENT FOR SIMULTANEOUS LIGHTENING AND COLORING OF KERATIN FIBRES CONTAINING A SULFAMATE BLEACH BOOSTER THE PROCTER & GAMBLE COMPANY (US) 2007-03-08 WO disclosed
WO-2006088973-A1 DYE CARRIER MASS THE PROCTER & GAMBLE COMPANY (US) 2006-08-24 WO disclosed
WO-2006060564-A2 PYRAZOLE AZOMETHINES AND COLORANTS CONTAINING THESE COMPOUNDS THE PROCTER & GAMBLE COMPANY (US) 2006-06-08 WO disclosed
WO-2004112736-A1 METHOD AND COMPOSITIONS FOR COLORING HAIR WITH TAURATE COPOLYMERS UNILEVER PLC (GB) 2004-12-29 WO disclosed
WO-2004047780-A1 METHOD AND KIT FOR THE GRADUAL PERMANENT COLORING OF HAIR UNILEVER PLC (GB) 2004-06-10 WO disclosed
US-6503282-B1 Composition for coloring keratin fibers based on a developer-coupler combination characterized in that it contains as the coupler 3-(2,4-diaminophenoxy)-1-propanol and as the developer ring and having general formula (I) WELLA AKTIENGESELLSCHAFT (DE) 2003-01-07 US disclosed
WO-2002067882-A1 HAIR COLORANT IN THE FORM OF A CREAMY PERMANENT MOUSSE OR A STABLE FOAMED CREME COLORANT WELLA AKTIENGESELLSCHAFT (DE) 2002-09-06 WO disclosed
EP-1189576-A2 HAIR COMPOSITION COMPRISING AN OXIDASE AND CYCLODEXTRIN Lion Corporation (JP) 2002-03-27 EP disclosed
WO-2001068042-A1 METHOD FOR DYEING DRY HAIR NOVOZYMES A/S (DK) 2001-09-20 WO disclosed
WO-2001000144-A2 HAIR COMPOSITION COMPRISING AN OXIDASE AND CYCLODEXTRIN LION CORPORATION (JP) 2001-01-04 WO disclosed