Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14306821 | 0.90 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBMEN1KMT2AHRH2 | |
| SCHEMBL2925781 | 0.84 | KDM4E (0.44) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL29042818 | 0.84 | KDM4E (0.44) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL29307351 | 0.83 | ALDH1A1 (0.36) | KDM4EHPGDALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2925780 | 0.83 | KDM4E (0.43) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL12226495 | 0.81 | HRH2 (0.37) | KDM4EL3MBTL1HPGDALDH1A1MEN1 | |
| SCHEMBL12226502 | 0.81 | HRH2 (0.37) | KDM4EL3MBTL1HPGDALDH1A1MEN1 | |
| SCHEMBL7575787 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL1006794 | 0.79 | KDM4E (0.42) | POLBKDM4EL3MBTL1HPGDALDH1A1 | |
| SCHEMBL29307370 | 0.79 | HSD17B10 (0.38) | SMN1; SMN2KDM4EL3MBTL1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332509-B2 | Heterocyclic amides, a process for their preparation, compositions comprising them and their use | MERIAL LIMITED (US) | 2008-02-19 | — | — | US | disclosed |