SCHEMBL1430698

SCHEMBL1430698

Cc1cc(Cl)nc(CCl)c1C(=O)O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
MAPK1 P28482 2/20 0.58
TAAR1 Q96RJ0 1/20 0.43
CYP3A4 P08684 5/20 0.43
ACHE P22303 1/20 0.43
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
POLB P06746 1/20 0.40
KDM4E B2RXH2 5/20 0.38
CYP2C19 P33261 3/20 0.37
GPR35 Q9HC97 1/20 0.37
HIF1A Q16665 1/20 0.37
S1PR2 O95136 1/20 0.36
MAPT P10636 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
DAO P14920 1/20 0.34
HSD17B10 Q99714 2/20 0.34
HPGD P15428 1/20 0.34
ALOX15 P16050 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2129236 0.86 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2MAPK1TAAR1CYP3A4
SCHEMBL2130302 0.83 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2MAPK1TAAR1CYP3A4
SCHEMBL29384281 0.83 ALDH1A1 (0.74) ALDH1A1SMN1; SMN2MAPK1TAAR1CYP3A4
SCHEMBL473877 0.83 ALDH1A1 (0.74) ALDH1A1SMN1; SMN2MAPK1TAAR1CYP3A4
SCHEMBL612852 0.80 SMN1; SMN2 (0.52) ALDH1A1SMN1; SMN2MAPK1CYP3A4KDM4E
SCHEMBL31644242 0.80 SMN1; SMN2 (0.52) ALDH1A1SMN1; SMN2MAPK1CYP3A4KDM4E
SCHEMBL2132960 0.79 ALDH1A1 (0.63) ALDH1A1SMN1; SMN2MAPK1TAAR1CYP3A4
SCHEMBL11385463 0.78 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2MAPK1TAAR1CYP3A4
Hydrochloric Acid SCHEMBL3758009 0.78 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2MAPK1TAAR1CYP3A4
SCHEMBL25282673 0.76 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2MAPK1TAAR1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108602805-A Isoindoline, azaisoindoline, indenone and the dihydro azepine indone inhibitor of MNK1 and MNK2 效应治疗股份有限公司 2018-09-28 CN disclosed
CN-105722838-B Selective inhibitors of phosphatidylinositol 3-kinase-gamma 沃泰克斯药物股份有限公司 2017-10-24 CN disclosed
EP-2299816-A1 INHIBITORS OF JANUS KINASES Merck Sharp & Dohme Corp. (US) 2011-03-30 EP disclosed
WO-2009155156-A1 INHIBITORS OF JANUS KINASES MERCK & CO., INC. (US) 2009-12-23 WO disclosed