Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.36 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16178782 | 0.82 | CYP3A4 (0.38) | MAPTFLT3TYRO3MERTKGAS6 | |
| SCHEMBL352093 | 0.76 | JAK3 (0.49) | — | |
| SCHEMBL10062156 | 0.76 | JAK3 (0.49) | — | |
| SCHEMBL22584714 | 0.76 | ALOX15 (0.43) | CYP3A4TSHRCYP2D6CYP2C19HCRTR2 | |
| SCHEMBL22584709 | 0.75 | CYP3A4 (0.46) | MAPTCYP3A4TSHRCYP2D6EPHX2 | |
| SCHEMBL12811680 | 0.72 | ALDH1A1 (0.51) | MAPTPSMB5GAAACKR3 | |
| SCHEMBL1437846 | 0.72 | EPHX2 (0.50) | EPHX2PSMB5ACKR3 | |
| SCHEMBL8155144 | 0.72 | TSHR (0.47) | MAPTCYP3A4TSHRCYP2D6CYP2C19 | |
| SCHEMBL17964652 | 0.70 | PI4KB (0.61) | — | |
| SCHEMBL2070480 | 0.69 | NPSR1 (0.46) | MAPTTSHRCYP2C19CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335667-B2 | Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-4-yl-amines as Janus kinase inhibitors | INCYTE CORPORATION (US) | 2008-02-26 | — | — | US | disclosed |