Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 4/20 | 0.39 |
| ▸ | TEC | P42680 | 3/20 | 0.39 |
| ▸ | BMX | P51813 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | BLK | P51451 | 2/20 | 0.38 |
| ▸ | ITK | Q08881 | 2/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | FGR | P09769 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | FRK | P42685 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459116 | 0.80 | PIK3CD (0.59) | PIK3CDPIK3CBPIM1GSK3BPIK3CA | |
| SCHEMBL1119167 | 0.78 | PIK3CD (0.56) | PIK3CDPIK3CBPIM1GSK3BPIK3CA | |
| SCHEMBL1431437 | 0.77 | PIK3CD (0.55) | PIK3CDPIK3CBPIM1GSK3BPIK3CA | |
| SCHEMBL461789 | 0.76 | PIK3CD (0.48) | PIK3CDPIK3CBPIM1GSK3BPIK3CA | |
| SCHEMBL1431305 | 0.74 | PIK3CD (0.55) | PIK3CDPIK3CBPIM1GSK3BPIK3CA | |
| SCHEMBL2216485 | 0.74 | PIK3CD (0.58) | PIK3CDPIK3CBPIM1GSK3BPIK3CA | |
| SCHEMBL470091 | 0.73 | PIK3CD (0.58) | PIK3CDPIK3CBPIM1GSK3BPIK3CA | |
| SCHEMBL463054 | 0.73 | PIK3CD (0.51) | PIK3CDPIK3CBPIM1GSK3BPIK3CA | |
| SCHEMBL1430759 | 0.72 | PIK3CD (0.72) | PIK3CDPIK3CBPIM1GSK3BPIK3CA | |
| SCHEMBL1431039 | 0.72 | PIK3CD (0.49) | PIK3CDPIK3CBPIM1GSK3BPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300437-A1 | BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES | Glaxo Group Limited (GB) | 2011-03-30 | — | — | EP | disclosed |