Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | HPGDS | O60760 | 5/20 | 0.41 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.39 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.39 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.39 |
| ▸ | GRK2 | P25098 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1431305 | 0.79 | PIK3CD (0.55) | PIK3CDPIK3CBPIK3CAPIK3CGPIM1 | |
| SCHEMBL1119167 | 0.77 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CAPIK3CGPIM1 | |
| SCHEMBL461789 | 0.77 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CAPIK3CGPIM1 | |
| SCHEMBL459116 | 0.74 | PIK3CD (0.59) | PIK3CDPIK3CBPIK3CAPIK3CGPIM1 | |
| SCHEMBL1779661 | 0.74 | PIK3CD (0.77) | PIK3CDPIK3CBPIK3CAPIK3CGPIM1 | |
| SCHEMBL1431437 | 0.74 | PIK3CD (0.55) | PIK3CDPIK3CBPIK3CAPIK3CGPIM1 | |
| SCHEMBL1430757 | 0.73 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CAPIK3CGPIM1 | |
| SCHEMBL1252626 | 0.72 | PIK3CD (0.74) | PIK3CDPIK3CBPIK3CAPIK3CGPIM1 | |
| SCHEMBL462495 | 0.70 | PIK3CD (0.64) | PIK3CDPIK3CBPIK3CAPIK3CGPIM1 | |
| SCHEMBL1251740 | 0.70 | PIK3CD (0.76) | PIK3CDPIK3CBPIK3CAPIK3CGPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613781-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032065-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GLAXO GROUP LIMITED (GB) | 2012-03-15 | — | — | WO | disclosed |