SCHEMBL1430804

SCHEMBL1430804

[CH2]C(C)(C)CN1CCOCC1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
RECQL P46063 1/20 0.39
USP2 O75604 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
KDM4E B2RXH2 4/20 0.37
KEAP1 Q14145 1/20 0.37
GAA P10253 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
HSD17B10 Q99714 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
ALOX15 P16050 1/20 0.34
TSHR P16473 1/20 0.34
GLA P06280 1/20 0.33
LMNA P02545 1/20 0.33
CYP2A13 Q16696 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9863949 0.82 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2RECQLUSP2MEN1
SCHEMBL179555 0.80 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2RECQLUSP2MEN1
SCHEMBL10153213 0.78 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2RECQLUSP2MEN1
SCHEMBL18116866 0.77 ALDH1A1 (0.37) ALDH1A1SMN1; SMN2RECQLUSP2MEN1
SCHEMBL6075113 0.77 CARM1 (0.33) ALDH1A1SMN1; SMN2KDM4EGAATSHR
SCHEMBL862113 0.76 SMN1; SMN2 (0.41) ALDH1A1SMN1; SMN2RECQLUSP2MEN1
SCHEMBL17310700 0.76 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2RECQLUSP2MEN1
SCHEMBL17392772 0.76 SMN1; SMN2 (0.43) ALDH1A1SMN1; SMN2RECQLUSP2MEN1
SCHEMBL20623013 0.76 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2RECQLUSP2MEN1
SCHEMBL1708968 0.76 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2RECQLUSP2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2895517-B1 TWO-COMPONENT POLYURETHANE COMPOSITION SIKA TECH AG (CH) 2020-12-16 EP claimed
EP-2776488-B1 HARDENERS FOR EPOXY RESIN COATINGS SIKA TECHNOLOGY AG (CH) 2016-02-03 EP claimed
US-20150259465-A1 TWO-COMPONENT POLYURETHANE COMPOSITION SIKA TECHNOLOGY AG (CH) 2015-09-17 US claimed
CN-104640894-A Two-component polyurethane composition SIKA TECHNOLOGY AG 2015-05-20 CN claimed
US-20140309334-A1 CURING AGENT FOR EPOXY RESIN COATINGS SIKA TECHNOLOGY AG (CH) 2014-10-16 US claimed
EP-2776488-A1 HARDENERS FOR EPOXY RESIN COATINGS Sika Technology AG (CH) 2014-09-17 EP claimed
CN-103930462-A Hardeners for epoxy resin coatings SIKA TECHNOLOGY AG 2014-07-16 CN claimed
EP-2706073-A1 Two-component polyurethane composition Sika Technology AG (CH) 2014-03-12 EP claimed
WO-2013171200-A1 REACTIVE POLYURETHANE HOT-MELT ADHESIVES HAVING A LOW ISOCYANATE MONOMER CONTENT SIKA TECHNOLOGY AG (CH) 2013-11-21 WO claimed
EP-2664637-A1 Reactive polyurethane hot melt adhesives with low isocyanate monomer content Sika Technology AG (CH) 2013-11-20 EP claimed
WO-2013068501-A1 HARDENERS FOR EPOXY RESIN COATINGS SIKA TECHNOLOGY AG (CH) 2013-05-16 WO claimed
EP-2592100-A1 Curing agent for epoxy resin coatings Sika Technology AG (CH) 2013-05-15 EP claimed
EP-1664023-A1 SUSTITUTED ISOQUINOLINE DERIVATIVES AND METHODS OF USE AMGEN INC. (US) 2006-06-07 EP claimed
WO-2005021533-A1 SUBSTITUTED ISOQUINOLINE DERIVATIVES AND METHODS OF USE AMGEN INC (US) 2005-03-10 WO claimed
EP-2895517-B1 TWO-COMPONENT POLYURETHANE COMPOSITION SIKA TECH AG (CH) 2020-12-16 EP disclosed
US-9340701-B2 Curing agent for epoxy resin coatings SIKA TECHNOLOGY AG (CH) 2016-05-17 US disclosed
EP-2776488-B1 HARDENERS FOR EPOXY RESIN COATINGS SIKA TECHNOLOGY AG (CH) 2016-02-03 EP disclosed
WO-2004005279-A2 SUBSTITUTED ANTHRANILIC AMIDE DERIVATIVES AND METHODS OF USE AMGEN INC. (US) 2004-01-15 WO disclosed
US-5358949-A Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-10-25 US disclosed
EP-0236140-A2 Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1987-09-09 EP disclosed