Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4175269 | 0.88 | MEN1 (0.50) | MEN1KMT2ANPC1RAB9AFYN | |
| SCHEMBL4171927 | 0.84 | FYN (0.67) | MEN1KMT2ANPC1RAB9AFYN | |
| SCHEMBL13914415 | 0.77 | GPR119 (0.38) | MEN1KMT2ANPC1RAB9AFYN | |
| SCHEMBL4173016 | 0.77 | LCK (0.40) | MEN1KMT2ANPC1RAB9AFYN | |
| SCHEMBL4695093 | 0.75 | FYN (0.68) | MEN1KMT2ANPC1RAB9AFYN | |
| SCHEMBL13905658 | 0.72 | MEN1 (0.61) | MEN1KMT2ANPC1RAB9AFYN | |
| SCHEMBL4168402 | 0.70 | KMT2A (0.58) | MEN1KMT2ANPC1RAB9AFYN | |
| SCHEMBL4695452 | 0.69 | FYN (0.60) | MEN1KMT2ANPC1RAB9AFYN | |
| SCHEMBL4167662 | 0.69 | FYN (0.59) | MEN1KMT2ANPC1RAB9AFYN | |
| SCHEMBL4179850 | 0.69 | FYN (0.71) | MEN1KMT2ANPC1RAB9AFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007103432-A9 | USE OF PYRAZOLO[1,5A]PYRIMIDIN-7-YL AMINE DERIVATIVES IN THE TREATMENT OF NEUROLOGICAL DISORDERS | NOVARTIS AG (CH) | 2008-01-10 | — | — | WO | disclosed |