Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.39 |
| ▸ | PLK4 | O00444 | 6/20 | 0.38 |
| ▸ | HPGDS | O60760 | 2/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312803 | 0.93 | MET (0.39) | PTGS2PLK4HPGDSSCDPAK4 | |
| SCHEMBL14312729 | 0.90 | MET (0.39) | HPGDSMET | |
| SCHEMBL14312743 | 0.88 | HPGDS (0.42) | PTGS2PLK4HPGDSSCDPAK4 | |
| SCHEMBL12083762 | 0.87 | HPGDS (0.43) | PTGS2PLK4HPGDSSCDPAK4 | |
| SCHEMBL14313316 | 0.86 | CYP11B1 (0.40) | PTGS2PTGS1 | |
| SCHEMBL14313417 | 0.86 | MET (0.39) | HPGDSMET | |
| SCHEMBL14313117 | 0.83 | HPGDS (0.38) | HPGDSNTRK1MET | |
| SCHEMBL14313213 | 0.82 | KDM4A (0.42) | PTGS2HPGDSSCDPTGS1 | |
| SCHEMBL12083923 | 0.81 | HPGDS (0.54) | PTGS2PLK4HPGDSSCDPAK4 | |
| SCHEMBL12083682 | 0.79 | HPGDS (0.43) | PTGS2PLK4HPGDSSCDPAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |