Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F12 | P00748 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | SCN2B | O60939 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313161 | 0.91 | HPGDS (0.48) | HPGDSKMT2APPP1CAMETAP1SMN1; SMN2 | |
| SCHEMBL14312953 | 0.89 | HPGDS (0.73) | HPGDSKMT2APPP1CASMN1; SMN2F2 | |
| SCHEMBL12084132 | 0.85 | HPGDS (0.79) | HPGDSKMT2APPP1CAMETAP1BRAF | |
| SCHEMBL14312581 | 0.85 | HPGDS (0.51) | HPGDSKMT2APPP1CAMETAP1SMN1; SMN2 | |
| SCHEMBL14313251 | 0.84 | HPGDS (0.54) | HPGDSKMT2APPP1CASMN1; SMN2MEN1 | |
| SCHEMBL14313156 | 0.84 | HPGDS (0.64) | HPGDSKMT2APPP1CASMN1; SMN2CYP1A2 | |
| SCHEMBL14313203 | 0.83 | HPGDS (0.52) | HPGDSKMT2APPP1CASMN1; SMN2MEN1 | |
| SCHEMBL14313001 | 0.82 | HPGDS (0.43) | HPGDS | |
| SCHEMBL14313066 | 0.81 | HPGDS (0.73) | HPGDSKMT2APPP1CASMN1; SMN2MEN1 | |
| SCHEMBL14313361 | 0.81 | HPGDS (0.60) | HPGDSKMT2APPP1CASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |