Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F12 | P00748 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313001 | 0.92 | HPGDS (0.43) | HPGDSL3MBTL1ALDH1A1 | |
| SCHEMBL14313110 | 0.91 | HPGDS (0.58) | HPGDSKMT2APPP1CACYP1A2CYP2C9 | |
| SCHEMBL12083840 | 0.86 | HPGDS (0.65) | HPGDSKMT2APPP1CACYP1A2CYP2C9 | |
| SCHEMBL14312984 | 0.85 | HPGDS (0.49) | HPGDSKMT2APPP1CACYP1A2CYP2C9 | |
| SCHEMBL14312398 | 0.85 | HPGDS (0.38) | HPGDSPTGS2 | |
| SCHEMBL14313340 | 0.85 | MAPK9 (0.35) | HPGDSL3MBTL1ALDH1A1NPC1RAB9A | |
| SCHEMBL14313181 | 0.84 | HPGDS (0.60) | HPGDSKMT2APPP1CAL3MBTL1KDM4E | |
| SCHEMBL14312693 | 0.83 | HPGDS (0.46) | HPGDSKMT2APPP1CAL3MBTL1KDM4E | |
| SCHEMBL14313050 | 0.83 | HPGDS (0.57) | HPGDSKMT2APPP1CACYP1A2L3MBTL1 | |
| SCHEMBL14312581 | 0.83 | HPGDS (0.51) | HPGDSKMT2APPP1CACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |