Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 4/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313439 | 0.89 | HPGDS (0.54) | HPGDSHCRTR1HCRTR2SCN9APSEN1 | |
| SCHEMBL14312802 | 0.87 | HPGDS (0.44) | HPGDSHCRTR1HCRTR2SCN9APSEN1 | |
| SCHEMBL14313193 | 0.87 | HPGDS (0.40) | HPGDSGRM5XDHPIK3CDPIK3R1 | |
| SCHEMBL12083746 | 0.85 | HPGDS (0.59) | HPGDSGRM5XDHARPIK3CD | |
| SCHEMBL14313346 | 0.83 | HPGDS (0.41) | HPGDSHCRTR1HCRTR2PSEN1PSEN2 | |
| SCHEMBL14313248 | 0.83 | HPGDS (0.41) | HPGDSMAP4K4HCRTR1HCRTR2 | |
| SCHEMBL14313409 | 0.83 | HPGDS (0.43) | HPGDSGRM5SCN9A | |
| SCHEMBL14313356 | 0.82 | HPGDS (0.51) | HPGDSGRM5HCRTR1HCRTR2PSEN1 | |
| SCHEMBL14312738 | 0.82 | HPGDS (0.39) | HPGDSGRM5XDHHCRTR1HCRTR2 | |
| SCHEMBL14313025 | 0.82 | HPGDS (0.46) | HPGDSSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |