Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312696 | 0.89 | HPGDS (0.43) | HPGDSNR3C2GRM5LMNAPSEN1 | |
| SCHEMBL14313322 | 0.87 | HPGDS (0.42) | HPGDSSCN9AGRM5XDHMAP4K4 | |
| SCHEMBL14312928 | 0.86 | HPGDS (0.41) | HPGDSTP53PSEN1PSEN2APH1B | |
| SCHEMBL12083963 | 0.85 | HPGDS (0.55) | HPGDSNR3C1NR3C2SCN9AGRM5 | |
| SCHEMBL14312798 | 0.85 | HPGDS (0.42) | HPGDSNR3C2GRM5LMNAPSEN1 | |
| SCHEMBL14312738 | 0.85 | HPGDS (0.39) | HPGDSGRM5XDHPSEN1PSEN2 | |
| SCHEMBL14313255 | 0.83 | HPGDS (0.42) | HPGDSGRM5LMNAPSEN1PSEN2 | |
| SCHEMBL14313134 | 0.83 | HPGDS (0.41) | HPGDS | |
| SCHEMBL14313248 | 0.81 | HPGDS (0.41) | HPGDSMAP4K4LMNATP53 | |
| SCHEMBL14312563 | 0.81 | HPGDS (0.41) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |