Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 14/20 | 0.54 |
| ▸ | RAB9A | P51151 | 14/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | STAT1 | P42224 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.52 |
| ▸ | RELA | Q04206 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14315443 | 0.91 | RAB9A (0.63) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL14315442 | 0.90 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL14317616 | 0.89 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL16403950 | 0.89 | RAB9A (0.52) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL16403945 | 0.89 | NFKB1 (0.60) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL16403925 | 0.88 | RAB9A (0.57) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL14315445 | 0.87 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL14325852 | 0.87 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL16404067 | 0.87 | RAB9A (0.50) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL16403941 | 0.87 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| WO-2012172438-A9 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2013-02-07 | — | — | WO | disclosed |
| WO-2012172438-A2 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2012-12-20 | — | — | WO | disclosed |