Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14317877 | 0.90 | NPSR1 (0.49) | SMN1; SMN2NPC1RAB9ANPSR1POLB | |
| SCHEMBL14246970 | 0.85 | HPGD (0.55) | SMN1; SMN2NPC1RAB9ANPSR1POLB | |
| SCHEMBL14246842 | 0.85 | NPSR1 (0.49) | SMN1; SMN2NPC1RAB9ANPSR1POLB | |
| SCHEMBL14246812 | 0.82 | NPSR1 (0.50) | SMN1; SMN2NPC1RAB9ANPSR1POLB | |
| SCHEMBL14317872 | 0.80 | DYRK1A (0.56) | SMN1; SMN2NPC1RAB9ANPSR1POLB | |
| SCHEMBL14315169 | 0.79 | NPSR1 (0.53) | SMN1; SMN2NPC1RAB9ANPSR1POLB | |
| SCHEMBL14246841 | 0.77 | NPSR1 (0.46) | SMN1; SMN2NPC1RAB9ANPSR1POLB | |
| SCHEMBL14246746 | 0.77 | CD274 (0.54) | SMN1; SMN2NPC1RAB9ANPSR1POLB | |
| SCHEMBL14317875 | 0.76 | LMNA (0.51) | SMN1; SMN2NPSR1POLBLMNAKMT2A | |
| SCHEMBL14246865 | 0.74 | DYRK1A (0.56) | SMN1; SMN2NPC1RAB9ANPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174488-A2 | AGENTS AND METHODS FOR TREATING ISCHEMIC AND OTHER DISEASES | NONO, INC. (CA) | 2012-12-20 | — | — | WO | disclosed |