Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.36 |
| ▸ | RORC | P51449 | 5/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462217 | 0.82 | PIK3CD (0.47) | HTR6RORCHTR1AHTR7HTR2B | |
| SCHEMBL456826 | 0.81 | ALDH1A1 (0.44) | HDAC1 | |
| SCHEMBL1431436 | 0.79 | TSHR (0.48) | HTR6RORCOPRM1 | |
| SCHEMBL2216043 | 0.79 | HTR6 (0.36) | HTR6RORCHTR1AHTR7HTR2B | |
| SCHEMBL2214904 | 0.79 | EGFR (0.34) | HTR6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL458467 | 0.72 | HTR6 (0.43) | HTR6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1432113 | 0.69 | HTR6 (0.39) | HTR6PIK3CDPIK3CAPIK3CGHDAC3 | |
| SCHEMBL1251686 | 0.67 | PIK3CD (0.62) | HTR6PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL110249 | 0.66 | HTR6 (0.43) | HTR6OPRM1HDAC3HDAC4HDAC1 | |
| SCHEMBL1431711 | 0.65 | PIK3CD (0.51) | HTR6PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300437-A1 | BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES | Glaxo Group Limited (GB) | 2011-03-30 | — | — | EP | disclosed |