Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 4/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 3/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14321706 | 0.92 | ELANE (0.38) | CYP4F2CYP4A11TBXA2RELANESLC5A1 | |
| SCHEMBL14321836 | 0.77 | TBXA2R (0.65) | TBXA2R | |
| SCHEMBL16147917 | 0.75 | ELANE (0.47) | ELANEFAAH | |
| SCHEMBL14321347 | 0.73 | TBXA2R (0.65) | CYP4F2CYP4A11TBXA2RSLC5A1 | |
| SCHEMBL14321853 | 0.72 | TBXA2R (0.51) | CYP4F2CYP4A11TBXA2R | |
| SCHEMBL14321480 | 0.71 | TBXA2R (0.66) | CYP4F2CYP4A11TBXA2R | |
| SCHEMBL14321554 | 0.71 | TBXA2R (0.64) | CYP4F2CYP4A11TBXA2R | |
| SCHEMBL8048495 | 0.71 | CYP4F2 (0.61) | CYP4F2CYP4A11FAAH | |
| SCHEMBL14324810 | 0.69 | TBXA2R (0.64) | TBXA2R | |
| SCHEMBL14321527 | 0.68 | TBXA2R (0.41) | CYP4F2CYP4A11TBXA2RSLC5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8530520-B2 | Cycloalkyl-dione derivatives and methods of their use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-09-10 | — | — | US | disclosed |
| US-8530520-B2 | Cycloalkyl-dione derivatives and methods of their use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-09-10 | — | — | US | disclosed |
| US-8530520-B2 | Cycloalkyl-dione derivatives and methods of their use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-09-10 | — | — | US | disclosed |
| US-20120329877-A1 | Cycloalkyl-dione Derivatives And Methods Of Their Use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-12-27 | — | — | US | disclosed |
| US-20120329877-A1 | Cycloalkyl-dione Derivatives And Methods Of Their Use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-12-27 | — | — | US | disclosed |
| US-20120329877-A1 | Cycloalkyl-dione Derivatives And Methods Of Their Use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329877-A1 | Cycloalkyl-dione Derivatives And Methods Of Their Use | CYP11B2, CYP1B1, SQLE | CYP4F2 250/4885CYP4A11 105/4885TBXA2R 80/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.