Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19334564 | 0.78 | MAPT (0.53) | GAAALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL7473537 | 0.78 | CA1 (0.55) | GAACA1MMP2CA14ALDH1A1 | |
| SCHEMBL10959519 | 0.77 | ALDH1A1 (0.47) | CA14ALDH1A1RAB9ARAPGEF4MAPT | |
| SCHEMBL19334573 | 0.77 | CA12 (0.50) | MMP2CA14ALDH1A1HPGDRAPGEF4 | |
| SCHEMBL15928729 | 0.77 | MAPT (0.47) | GAAALDH1A1SMN1; SMN2RAB9ARAPGEF4 | |
| Hydrochloric Acid SCHEMBL5234166 | 0.76 | CA1 (0.53) | GAACA1MMP2CA14ALDH1A1 | |
| SCHEMBL11674687 | 0.76 | CA1 (0.53) | GAACA1MMP2CA14ALDH1A1 | |
| SCHEMBL2495982 | 0.74 | TDP1 (0.54) | GAAALDH1A1SMN1; SMN2POLBMEN1 | |
| SCHEMBL790339 | 0.74 | MEN1 (0.52) | GAACA1MMP2CA14ALDH1A1 | |
| SCHEMBL1419332 | 0.74 | EGFR (0.56) | GAACA1MMP2CA14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300463-A1 | HETEROCYCLIC UREA DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009147433-A1 | HETEROCYCLIC UREA DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2009-12-10 | — | — | WO | disclosed |