Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | GPR3 | P46089 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | TNKS | O95271 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.55 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | IDE | P14735 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30539933 | 1.00 | PARP1 (0.57) | PARP1KDM4EALDH1A1GPR3HSD17B10 | |
| SCHEMBL6046876 | 0.86 | PARP1 (0.57) | PARP1KDM4EALDH1A1GPR3HSD17B10 | |
| SCHEMBL27375337 | 0.77 | PTGES (0.45) | PARP1KDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL26907188 | 0.73 | ALDH1A1 (0.52) | PARP1KDM4EALDH1A1GPR3HSD17B10 | |
| SCHEMBL30136559 | 0.73 | ALDH1A1 (0.52) | PARP1KDM4EALDH1A1GPR3HSD17B10 | |
| SCHEMBL17293 | 0.72 | PARP1 (1.00) | PARP1KDM4EALDH1A1GPR3HSD17B10 | |
| SCHEMBL29593478 | 0.72 | PARP1 (1.00) | PARP1KDM4EALDH1A1GPR3HSD17B10 | |
| SCHEMBL31326568 | 0.72 | PARP1 (1.00) | PARP1KDM4EALDH1A1GPR3HSD17B10 | |
| SCHEMBL30090619 | 0.72 | PARP1 (1.00) | PARP1KDM4EALDH1A1GPR3HSD17B10 | |
| SCHEMBL27919701 | 0.72 | MAPT (0.37) | KDM4EALDH1A1GPR3HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112521387-B | NLRP3 modulators | 先天肿瘤免疫公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-112521387-A | NLRP3 modulators | 先天肿瘤免疫公司 | 2021-03-19 | — | — | CN | disclosed |
| CN-112074516-A | NLRP3 modulators | 先天肿瘤免疫公司 | 2020-12-11 | — | — | CN | disclosed |
| US-9499535-B2 | Kinase inhibitors | ORIGENIS GMBH (DE) | 2016-11-22 | — | — | US | disclosed |
| US-9499535-B2 | Kinase inhibitors | ORIGENIS GMBH (DE) | 2016-11-22 | — | — | US | disclosed |
| EP-2699572-B1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2016-08-10 | — | — | EP | disclosed |
| US-20120329785-A1 | Novel kinase inhibitors | ORIGENIS GMBH (DE) | 2012-12-27 | — | — | US | disclosed |
| US-20120329785-A1 | Novel kinase inhibitors | ORIGENIS GMBH (DE) | 2012-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329785-A1 | Novel kinase inhibitors | LRRK2, MYLK2, MYLK3 | PARP1 3006/4885KDM4E 1843/4885ALDH1A1 4394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.