Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14327089 | 0.71 | CFTR (0.38) | — | |
| SCHEMBL14313199 | 0.65 | TYRO3 (0.53) | — | |
| SCHEMBL14313868 | 0.64 | TYRO3 (0.53) | — | |
| SCHEMBL14312849 | 0.64 | TYRO3 (0.52) | — | |
| SCHEMBL14312685 | 0.64 | MERTK (0.44) | — | |
| SCHEMBL14327110 | 0.64 | ACVRL1 (0.42) | — | |
| SCHEMBL14313867 | 0.63 | TYRO3 (0.45) | — | |
| SCHEMBL14313069 | 0.63 | TYRO3 (0.46) | — | |
| SCHEMBL5074847 | 0.62 | ACVRL1 (0.61) | — | |
| SCHEMBL14327120 | 0.62 | TYRO3 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-B1 | PYRROLO[2,1-F] [1,2,4]-TRIAZIN-4-YLAMINES AS IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer Pharma AG (DE) | 2012-12-26 | — | — | EP | disclosed |