Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 6/20 | 0.42 |
| ▸ | CFTR | P13569 | 8/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14327089 | 0.79 | CFTR (0.38) | ACVRL1CFTRRIPK1RET | |
| SCHEMBL5077435 | 0.74 | ACVRL1 (0.56) | ACVRL1RIPK1 | |
| SCHEMBL14327086 | 0.74 | RIPK1 (0.36) | RIPK1RET | |
| SCHEMBL14327061 | 0.73 | ACVRL1 (0.36) | ACVRL1CFTRRIPK1RET | |
| SCHEMBL14531772 | 0.73 | ACVRL1 (0.45) | ACVRL1 | |
| SCHEMBL14898503 | 0.72 | TYRO3 (0.51) | ACVRL1 | |
| SCHEMBL14312813 | 0.72 | ACVRL1 (0.43) | ACVRL1CFTRRIPK1RET | |
| SCHEMBL5077162 | 0.70 | ACVRL1 (0.46) | ACVRL1RIPK1 | |
| SCHEMBL14531789 | 0.70 | CFTR (0.34) | ACVRL1CFTRRIPK1 | |
| SCHEMBL5077843 | 0.66 | ADORA3 (0.38) | ACVRL1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-B1 | PYRROLO[2,1-F] [1,2,4]-TRIAZIN-4-YLAMINES AS IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer Pharma AG (DE) | 2012-12-26 | — | — | EP | disclosed |