Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.33 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14712261 | 1.00 | JAK2 (0.40) | JAK2JAK3TNIKROCK2ROCK1 | |
| SCHEMBL14327540 | 0.81 | CCNK (0.34) | — | |
| SCHEMBL14327604 | 0.77 | JAK2 (0.40) | JAK2TNIKROCK2ROCK1CDC42BPB | |
| SCHEMBL14327601 | 0.75 | JAK2 (0.49) | JAK2 | |
| SCHEMBL17425350 | 0.70 | JAK3 (0.34) | JAK2JAK3 | |
| SCHEMBL14712346 | 0.69 | JAK2 (0.41) | JAK2TNIKROCK2 | |
| SCHEMBL14327539 | 0.66 | BTK (0.37) | JAK2 | |
| SCHEMBL14327576 | 0.63 | JAK2 (0.39) | JAK2 | |
| SCHEMBL10304562 | 0.63 | LATS1 (0.41) | JAK2JAK3CDC42BPA | |
| SCHEMBL14712260 | 0.63 | JAK2 (0.35) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2537849-A2 | Azaindoles useful as inhibitors of janus kinases | Vertex Pharmaceuticals, Inc. (US) | 2012-12-26 | — | — | EP | disclosed |