Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14327615 | 0.77 | JAK2 (0.40) | JAK2TNIKROCK2ROCK1CDC42BPB | |
| SCHEMBL14712261 | 0.77 | JAK2 (0.40) | JAK2TNIKROCK2ROCK1CDC42BPB | |
| SCHEMBL14327601 | 0.76 | JAK2 (0.49) | JAK2KIT | |
| SCHEMBL14327598 | 0.69 | JAK2 (0.38) | JAK2MAPK1 | |
| SCHEMBL14327540 | 0.69 | CCNK (0.34) | — | |
| SCHEMBL14712346 | 0.68 | JAK2 (0.41) | JAK2TNIKROCK2KIT | |
| SCHEMBL17425350 | 0.67 | JAK3 (0.34) | JAK2 | |
| SCHEMBL14712318 | 0.62 | CDC7 (0.51) | JAK2MAPK1LRRK2ROCK2ROCK1 | |
| SCHEMBL14327539 | 0.62 | BTK (0.37) | JAK2 | |
| SCHEMBL14712260 | 0.62 | JAK2 (0.35) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2537849-A2 | Azaindoles useful as inhibitors of janus kinases | Vertex Pharmaceuticals, Inc. (US) | 2012-12-26 | — | — | EP | disclosed |