Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14327601 | 0.76 | JAK2 (0.49) | JAK2CDK2CYP3A4CYP2D6KIT | |
| SCHEMBL14712260 | 0.74 | JAK2 (0.35) | JAK2BRAFFLT3TYRO3MERTK | |
| SCHEMBL14327539 | 0.71 | BTK (0.37) | JAK2IRAK4 | |
| SCHEMBL14327614 | 0.70 | CLK4 (0.46) | JAK2MAP4K4HIPK2CDC7ROCK2 | |
| SCHEMBL14327540 | 0.70 | CCNK (0.34) | CDK2 | |
| SCHEMBL14712261 | 0.69 | JAK2 (0.40) | JAK2ROCK2TNIK | |
| SCHEMBL14327615 | 0.69 | JAK2 (0.40) | JAK2ROCK2TNIK | |
| SCHEMBL14327604 | 0.68 | JAK2 (0.40) | JAK2ROCK2TNIKKIT | |
| SCHEMBL1891225 | 0.66 | CYP2C9 (0.62) | JAK2UTS2RCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14327581 | 0.65 | JAK2 (0.35) | JAK2MAP4K4HIPK2BRAFFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2559694-A2 | Azaindoles useful as inhibitors of Janus kinases | Vertex Pharmaceuticals, Inc. (US) | 2013-02-20 | — | — | EP | disclosed |