Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14333835 | 0.81 | POLB (0.38) | HTR2AALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL14334416 | 0.78 | CYP19A1 (0.39) | HTR2AALDH1A1MAPTGRIN2DGRIN3B | |
| SCHEMBL2300342 | 0.76 | MAPT (0.39) | FBP1ALDH1A1MAPTSMN1; SMN2GRIN2D | |
| SCHEMBL14334267 | 0.76 | MAPT (0.41) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4299437 | 0.76 | ALDH1A1 (0.47) | FBP1ALDH1A1MAPTSMN1; SMN2CRHBP | |
| SCHEMBL12011132 | 0.73 | MAPT (0.37) | ALDH1A1MAPTSMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL12403214 | 0.72 | MAPT (0.38) | ALDH1A1MAPTSMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL19224611 | 0.72 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL13532049 | 0.71 | MAPT (0.45) | ALDH1A1MAPTSMN1; SMN2CRHBPCRHR2 | |
| SCHEMBL19228571 | 0.71 | ALDH1A1 (0.40) | ALDH1A1MAPTSMN1; SMN2GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140205537-A1 | LRRK2 INHIBITORS | ZENOBIA THERAPEUTICS, INC. (US) | 2014-07-24 | — | — | US | disclosed |
| WO-2012178015-A2 | LRRK2 INHIBITORS | ZENOBIA THERAPEUTICS, INC. (US) | 2012-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140205537-A1 | LRRK2 INHIBITORS | LRRK2, PARK7, MAP2 | HTR2A 1369/4885FBP1 3008/4885ALDH1A1 4546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.