Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14377498 | 0.95 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL14335050 | 0.93 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL29741462 | 0.84 | CYP1A2 (0.59) | ALDH1A1MAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL3336130 | 0.84 | CYP1A2 (0.59) | ALDH1A1MAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL14376986 | 0.81 | GPR119 (0.44) | GPR119POLB | |
| SCHEMBL31343918 | 0.78 | SMN1; SMN2 (0.62) | ALDH1A1MAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL14377500 | 0.78 | GPR119 (0.47) | GRM5GPR119POLB | |
| SCHEMBL31013547 | 0.77 | PRKCQ (0.52) | ALDH1A1MAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL14377209 | 0.76 | CYP1A2 (0.62) | ALDH1A1MAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL14377365 | 0.76 | ALDH1A1 (0.59) | ALDH1A1MAPTLMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012176123-A1 | 3 - IMIDAZOLYL- INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2012-12-27 | — | — | WO | disclosed |
| WO-2012176123-A1 | 3 - IMIDAZOLYL- INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2012-12-27 | — | — | WO | disclosed |