Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28492945 | 0.90 | MAPT (0.51) | MAPTMAPK1TDP1ALDH1A1HTT | |
| SCHEMBL23850391 | 0.85 | ALDH1A1 (0.65) | MAPTMAPK1TDP1ALDH1A1HTT | |
| SCHEMBL31587859 | 0.85 | ALDH1A1 (0.65) | MAPTMAPK1TDP1ALDH1A1HTT | |
| SCHEMBL14335725 | 0.83 | MAPT (0.51) | MAPTMAPK1TDP1ALDH1A1HTT | |
| SCHEMBL14335724 | 0.82 | MAPT (0.50) | MAPTMAPK1TDP1ALDH1A1HTT | |
| SCHEMBL14377006 | 0.81 | MAPK1 (0.71) | MAPTMAPK1ALDH1A1HTTGAA | |
| SCHEMBL23851510 | 0.81 | MAPT (0.59) | MAPTMAPK1TDP1ALDH1A1HTT | |
| SCHEMBL23850169 | 0.80 | MAPT (0.58) | MAPTMAPK1TDP1ALDH1A1HTT | |
| SCHEMBL20524573 | 0.80 | MAPT (0.62) | MAPTMAPK1TDP1ALDH1A1HTT | |
| SCHEMBL31587565 | 0.80 | MAPT (0.58) | MAPTMAPK1TDP1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012176123-A1 | 3 - IMIDAZOLYL- INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2012-12-27 | — | — | WO | disclosed |
| WO-2012176123-A1 | 3 - IMIDAZOLYL- INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2012-12-27 | — | — | WO | disclosed |