Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951303 | 0.78 | KDM4E (0.38) | KDM4EKMT2AMAPTMEN1LMNA | |
| SCHEMBL24713060 | 0.75 | KDM4E (0.42) | KDM4EKMT2AMAPTMEN1LMNA | |
| SCHEMBL9475769 | 0.73 | XDH (0.41) | KDM4EKMT2AMAPTSMN1; SMN2HTT | |
| SCHEMBL25982008 | 0.73 | TSHR (0.38) | KDM4EKMT2AMAPTMEN1LMNA | |
| SCHEMBL10935150 | 0.73 | KDM4E (0.42) | KDM4EKMT2AMAPTMEN1LMNA | |
| SCHEMBL18851517 | 0.73 | KDM4E (0.35) | KDM4EKMT2AMAPTMEN1LMNA | |
| SCHEMBL6630371 | 0.72 | KDM4E (0.43) | KDM4EKMT2AMAPTMEN1LMNA | |
| SCHEMBL240599 | 0.72 | KDM4E (0.48) | KDM4EKMT2AMAPTMEN1LMNA | |
| SCHEMBL29420723 | 0.72 | KDM4E (0.48) | KDM4EKMT2AMAPTMEN1LMNA | |
| SCHEMBL1796492 | 0.71 | CD44 (0.42) | KDM4EKMT2AMAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304084-B2 | 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2007-12-04 | — | — | US | disclosed |