Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24433601 | 0.74 | HTR7 (0.41) | AOC3TAAR1 | |
| SCHEMBL21902241 | 0.72 | CARM1 (0.62) | PYCR1AOC3TAAR1ACHEPRMT1 | |
| SCHEMBL14868787 | 0.72 | AOC3 (0.47) | AOC3TAAR1SIGMAR1 | |
| SCHEMBL14869007 | 0.71 | PIM1 (0.48) | AOC3CARM1TSHR | |
| SCHEMBL3156765 | 0.71 | PYCR1 (0.58) | PYCR1AOC3TAAR1ACHEMCHR1 | |
| SCHEMBL15308498 | 0.71 | PYCR1 (0.61) | PYCR1AOC3TAAR1ACHEPRMT1 | |
| SCHEMBL14868818 | 0.70 | AOC3 (0.50) | AOC3TAAR1SIGMAR1 | |
| SCHEMBL30093221 | 0.69 | PYCR1 (0.67) | PYCR1AOC3TAAR1ACHETSHR | |
| SCHEMBL14149935 | 0.68 | PYCR1 (0.58) | PYCR1AOC3TAAR1ACHETSHR | |
| SCHEMBL14869312 | 0.68 | TSHR (0.40) | TAAR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0911330-B1 | 1-(4-Arylpiperazine-1-y1)-3-(2-oxopyrrolidin/piperidin-1-y1) propanes as therapeutic agents for hypertension, ischemia, cardiovascular and other adrenergic receptors related disorders | COUNCIL SCIENT IND RES (IN) | 2007-12-12 | — | — | EP | disclosed |