Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 5/20 | 0.40 |
| ▸ | HTR6 | P50406 | 7/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 3/20 | 0.35 |
| ▸ | CPT1B | Q92523 | 3/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206534 | 0.83 | HTR6 (0.52) | SLC1A3SLC1A2SLC1A1MEN1KMT2A | |
| SCHEMBL9372613 | 0.76 | SLC1A3 (0.59) | SLC1A3SLC1A2SLC1A1MEN1KMT2A | |
| SCHEMBL30554778 | 0.76 | SLC1A3 (0.59) | SLC1A3SLC1A2SLC1A1MEN1KMT2A | |
| SCHEMBL8284544 | 0.75 | HTR6 (0.63) | MEN1KMT2AHTR6HDAC8HDAC3 | |
| SCHEMBL7832462 | 0.74 | FABP4 (0.47) | SLC1A3SLC1A2SLC1A1MEN1KMT2A | |
| SCHEMBL6583538 | 0.71 | CYP2A6 (0.49) | L3MBTL1 | |
| SCHEMBL14340649 | 0.69 | HTR6 (0.54) | SLC1A3SLC1A2SLC1A1MEN1KMT2A | |
| SCHEMBL5202098 | 0.68 | HTR6 (0.52) | SLC1A3SLC1A2SLC1A1MEN1KMT2A | |
| SCHEMBL758075 | 0.67 | MAPK11 (0.38) | HDAC8 | |
| SCHEMBL7238170 | 0.67 | OXER1 (0.45) | KMT2AHDAC8L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | disclosed |