SCHEMBL14342131

SCHEMBL14342131

Cc1ccc(Oc2ccc(N3C(=O)C4CC5C(=O)N(C)C(=O)C5C4C3=O)cc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
TP53 P04637 1/20 0.45
GAA P10253 1/20 0.40
ALDH1A1 P00352 2/20 0.40
POLB P06746 1/20 0.40
ACHE P22303 1/20 0.39
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
CACNA1B Q00975 1/20 0.38
APBA1 Q02410 1/20 0.38
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
F2 P00734 1/20 0.37
ELANE P08246 1/20 0.37
CTSG P08311 1/20 0.37
CMA1 P23946 1/20 0.37
CTRC Q99895 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9911156 0.92 LMNA (0.49) LMNASMN1; SMN2TP53GAAALDH1A1
SCHEMBL13624488 0.88 LMNA (0.46) LMNASMN1; SMN2TP53ALDH1A1POLB
SCHEMBL12539789 0.87 TP53 (0.49) LMNASMN1; SMN2TP53GAAALDH1A1
SCHEMBL12799504 0.85 TP53 (0.47) LMNASMN1; SMN2TP53GAAALDH1A1
SCHEMBL12137897 0.85 TP53 (0.47) LMNASMN1; SMN2TP53GAAALDH1A1
SCHEMBL14208340 0.84 SMN1; SMN2 (0.46) LMNASMN1; SMN2TP53GAAALDH1A1
SCHEMBL13400440 0.84 LMNA (0.48) LMNASMN1; SMN2TP53GAAALDH1A1
SCHEMBL13472599 0.84 LMNA (0.43) LMNASMN1; SMN2TP53ALDH1A1POLB
SCHEMBL13855427 0.83 TP53 (0.46) LMNASMN1; SMN2TP53GAAALDH1A1
SCHEMBL10028907 0.83 LMNA (0.37) LMNASMN1; SMN2TP53GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8642181-B2 Metal-clad white laminate MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2014-02-04 US disclosed
US-20070292709-A1 Metal-Clad White Laminate MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2007-12-20 US disclosed