SCHEMBL10028907

SCHEMBL10028907

C=CC1C2C(=O)N(C)C(=O)C2CC2C(=O)N(c3ccc(Oc4ccc(C(C)(C)c5ccc(Oc6ccc(C)cc6)cc5)cc4)cc3)C(=O)C21

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
TP53 P04637 1/20 0.34
KMT2A Q03164 2/20 0.34
ALDH1A1 P00352 2/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
POLB P06746 1/20 0.32
GAA P10253 1/20 0.32
ADCY2 Q08462 3/20 0.32
ACHE P22303 1/20 0.31
MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13472599 0.87 LMNA (0.43) LMNASMN1; SMN2TP53KMT2AALDH1A1
SCHEMBL14342131 0.83 LMNA (0.46) LMNASMN1; SMN2TP53KMT2AALDH1A1
SCHEMBL13773285 0.83 TP53 (0.42) LMNASMN1; SMN2TP53KMT2AALDH1A1
SCHEMBL12589254 0.82 SMN1; SMN2 (0.42) LMNASMN1; SMN2TP53KMT2AALDH1A1
SCHEMBL19399222 0.80 LMNA (0.48) LMNATP53ALDH1A1POLBGAA
SCHEMBL16201610 0.80 LMNA (0.48) LMNATP53ALDH1A1POLBGAA
SCHEMBL14076704 0.79 TP53 (0.41) LMNASMN1; SMN2TP53KMT2AALDH1A1
SCHEMBL15746109 0.79 TP53 (0.41) LMNASMN1; SMN2TP53KMT2AALDH1A1
SCHEMBL6365242 0.79 TP53 (0.41) LMNASMN1; SMN2TP53KMT2AALDH1A1
SCHEMBL16201615 0.79 LMNA (0.40) LMNASMN1; SMN2TP53KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8273439-B2 Release layer materials, substrate structures comprising the same and fabrication method thereof INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2012-09-25 US disclosed
US-8207256-B2 Organic/inorganic hybrid material and fabrication method thereof INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2012-06-26 US disclosed
US-20110130495-A1 ORGANIC/INORGANIC HYBRID MATERIAL AND FABRICATION METHOD THEREOF INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2011-06-02 US disclosed
US-20100143708-A1 RELEASE LAYER MATERIALS, SUBSTRATE STRUCTURES COMPRISING THE SAME AND FABRICATION METHOD THEREOF INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2010-06-10 US disclosed