Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.62 |
| ▸ | MMP3 | P08254 | 2/20 | 0.62 |
| ▸ | MMP13 | P45452 | 2/20 | 0.62 |
| ▸ | MMP8 | P22894 | 1/20 | 0.62 |
| ▸ | MMP12 | P39900 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10166856 | 0.89 | ADAMTS4 (0.65) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL10167211 | 0.89 | ADAMTS4 (0.77) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL13161184 | 0.89 | ADAMTS4 (0.69) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL13185641 | 0.85 | ADAMTS4 (0.77) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL10167821 | 0.85 | ADAMTS4 (0.77) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL14470033 | 0.82 | ADAMTS4 (0.66) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL14468358 | 0.81 | MMP13 (0.53) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL10166567 | 0.81 | MMP13 (0.63) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL8247095 | 0.80 | ADAMTS4 (0.63) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL10162022 | 0.80 | ADAMTS4 (0.63) | ADAMTS4MMP3MMP13MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139860-A2 | HETEROBICYLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |