Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 12/20 | 0.57 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.57 |
| ▸ | MMP3 | P08254 | 2/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP12 | P39900 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5425633 | 0.93 | MMP13 (0.55) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10168058 | 0.93 | MMP13 (0.64) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL14468359 | 0.91 | MMP13 (0.52) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL14446795 | 0.90 | MMP13 (0.54) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10167293 | 0.89 | MMP13 (0.64) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10167869 | 0.88 | MMP13 (0.66) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL5423763 | 0.87 | MMP13 (0.56) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10166977 | 0.87 | MMP13 (0.59) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL14446794 | 0.86 | MMP13 (0.54) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL14468358 | 0.86 | MMP13 (0.53) | MMP13ADAMTS4MMP3MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139860-A2 | HETEROBICYLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |