Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GPR6 | P46095 | 8/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2391270 | 0.92 | MAPT (0.40) | ALDH1A1MAPTFAAHACHEHTT | |
| SCHEMBL16908828 | 0.92 | MAPT (0.40) | ALDH1A1MAPTFAAHACHEHTT | |
| SCHEMBL12256688 | 0.85 | TDP1 (0.42) | ALDH1A1MAPTFAAHACHEHTT | |
| SCHEMBL12256706 | 0.85 | TDP1 (0.42) | ALDH1A1MAPTFAAHACHEHTT | |
| Trifluoroacetic Acid SCHEMBL2392336 | 0.84 | ALDH1A1 (0.44) | ALDH1A1MAPTGPR6FAAHACHE | |
| Trifluoroacetic Acid SCHEMBL2392333 | 0.84 | ALDH1A1 (0.44) | ALDH1A1MAPTGPR6FAAHACHE | |
| Trifluoroacetic Acid SCHEMBL2370294 | 0.84 | FAAH (0.38) | ALDH1A1MAPTGPR6FAAHACHE | |
| SCHEMBL2370291 | 0.84 | TDP1 (0.38) | ALDH1A1MAPTGPR6FAAHACHE | |
| Hydrochloric Acid SCHEMBL2369299 | 0.84 | TDP1 (0.41) | ALDH1A1MAPTFAAHACHEHTT | |
| Hydrochloric Acid SCHEMBL2369736 | 0.84 | TDP1 (0.41) | ALDH1A1MAPTFAAHACHEHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539345-B1 | 4-[CYCLOALKYLOXY(HETERO)ARYLAMINO]-THIENO[2,3-D]PYRIMIDINES HAVING MNK1/ MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2015-07-22 | — | — | EP | disclosed |
| US-8754079-B2 | Cycloalkyl containing thienopyrimidines for pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-06-17 | — | — | US | disclosed |
| EP-2539345-A1 | 4 - [CYCLOALKYLOXY (HETERO) ARYLAMINO]THIENO [2, 3 - D]PYRIMIDINES HAVING MNKL/ MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | Boehringer Ingelheim International GmbH (DE) | 2013-01-02 | — | — | EP | disclosed |