Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | BCR | P11274 | 3/20 | 0.51 |
| ▸ | SRC | P12931 | 3/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | PRKACG | P22612 | 1/20 | 0.47 |
| ▸ | PRKACB | P22694 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14348354 | 0.90 | JAK2 (0.54) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL8350600 | 0.86 | MAPK10 (0.44) | — | |
| SCHEMBL8349401 | 0.85 | JAK2 (0.53) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL8349351 | 0.85 | JAK2 (0.58) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL14348362 | 0.83 | JAK2 (0.56) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL4382875 | 0.83 | JAK2 (0.63) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL14338269 | 0.82 | JAK2 (0.47) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL8349109 | 0.76 | JAK2 (0.61) | JAK2ABL1BCRSRCEGFR | |
| SCHEMBL14348343 | 0.76 | ABL1 (0.54) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL14338271 | 0.76 | JAK2 (0.47) | JAK2HDAC1HDAC6ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |