Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | BCR | P11274 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | PRKACG | P22612 | 1/20 | 0.52 |
| ▸ | PRKACB | P22694 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14348343 | 0.93 | ABL1 (0.54) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL4382875 | 0.89 | JAK2 (0.63) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL8349351 | 0.89 | JAK2 (0.58) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL14348354 | 0.88 | JAK2 (0.54) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL14348352 | 0.83 | JAK2 (0.51) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL8349109 | 0.82 | JAK2 (0.61) | JAK2ABL1BCRSRCEGFR | |
| SCHEMBL8349401 | 0.81 | JAK2 (0.53) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL14338280 | 0.80 | JAK2 (0.49) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL4381980 | 0.79 | JAK2 (0.74) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL3015105 | 0.78 | CDK5 (0.60) | JAK2HDAC1HDAC6ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |