SCHEMBL14351998

SCHEMBL14351998

CCCCc1c(Cl)ccc([SiH3])c1C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYMP P19971 4/20 0.37
SKP2 Q13309 1/20 0.34
CFTR P13569 4/20 0.33
HTT P42858 2/20 0.33
NPC1 O15118 2/20 0.33
HPGD P15428 2/20 0.33
RAB9A P51151 2/20 0.33
MAPK1 P28482 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
ABL1 P00519 1/20 0.33
CTRC Q99895 1/20 0.33
SIGMAR1 Q99720 2/20 0.32
MAPT P10636 1/20 0.32
CCNB2 O95067 1/20 0.31
CDK1 P06493 1/20 0.31
CCNB1 P14635 1/20 0.31
GSK3A P49840 1/20 0.31
GSK3B P49841 1/20 0.31
CCNB3 Q8WWL7 1/20 0.31
SMN1; SMN2 Q16637 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2271479 0.86 TYMP (0.38) TYMPSKP2CFTRHTTNPC1
SCHEMBL15301727 0.81 TYMP (0.37) TYMPSKP2CFTRHTTNPC1
SCHEMBL15301407 0.77 CFTR (0.42) TYMPCFTRSMN1; SMN2MEN1KMT2A
SCHEMBL11910714 0.73 TAAR1 (0.54) CFTRHTTNPC1HPGDRAB9A
SCHEMBL12815493 0.72 CTRC (0.42) TYMPSKP2CFTRHTTNPC1
Ammonia Solution, Strong SCHEMBL10615574 0.71 CTRC (0.44) TYMPCFTRHTTNPC1HPGD
SCHEMBL31106934 0.70 ABL1 (0.41) TYMPSKP2CFTRHTTNPC1
SCHEMBL918736 0.69 CES1 (0.38) MAPTALDH1A1
SCHEMBL6232725 0.69 HPGD (0.46) CFTRHTTNPC1HPGDRAB9A
SCHEMBL2166705 0.69 MAPK1 (0.46) CFTRHTTNPC1HPGDRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8470947-B2 Ethylenic polymer SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-06-25 US disclosed
US-20130005931-A1 ETHYLENIC POLYMER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-01-03 US disclosed